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The Third Tiberium War is the third and most destructive global conflict between the Global Defense Initiative and the Brotherhood of Nod. During this war, Earth came under attack for the first time by an extraterrestrial race known as the Scrin. Nod exploited GDI's complacency and focus on Tiberium abatement after the previous conflicts, and discovered a weakness in their ion cannon network. After initially overrunning the United States, Nod was expelled from the country and GDI started a series of counterattacks, culminating in the Siege of Temple Prime in Sarajevo. At the end of the battle, an ion cannon blast caused an explosive reaction in a liquid Tiberium facility beneath the Temple, which attracted 6 Scrin vessels to the Earth.